• br Author contributions br Disclosures br Introduction

  2018-11-09

  

  Author contributions Disclosures Introduction Cardiovascular disease is the leading cause of morbidity and mortality in individuals with diabetes, with a 2–4 fold higher risk of cardiovascular disease and up to 3 fold higher risk of mortality compared to those without diabetes (Fox et al.,

• br Results br Discussion Despite the widespread clinical

  2018-11-08

  

  Results Discussion Despite the widespread clinical use of hMSCs, there are fundamental gaps in our knowledge of basic MSC biology. In contrast to HSCs, the molecular mechanisms that maintain MSCs in their undifferentiated state or determine their differentiation pathways are still poorly under

• Our results show that Exo has

  2018-11-08

  

  Our results show that Exo1 has a tissue-specific role in the maintenance of adult stem cell homeostasis: mice exhibited a significant defect in NSCs but not in HSCs. Exo1 deficiency resulted in a decrease in NSC proliferation, which was associated with increased expression of p21, whereas no signif

• Previous in vitro characterization of compensatory TSC

  2018-11-08

  

  Previous in vitro characterization of compensatory TSC differentiation was performed at 20% O2 with a dose of benzopyrene or hyperosmolar stress that activated maximal stress enzyme (Zhong et al., 2010; Xie et al., 2010). When O2 levels are optimized, the highest growth and the least stress (activat

• Inflammatory changes are observed in

  2018-11-08

  

  Inflammatory changes are observed in AD brains, particularly at the vicinity of senile plaques. They are abundant in activated microglia, which are the resident macrophages in the central nervous system, in both human AD samples (Mattiace et al., 1990; Perlmutter et al., 1990) and transgenic mouse m

• Despite published evidence that this prevalent

  2018-11-08

  

  Despite published evidence that this prevalent view was incorrect (Beltrami et al., 2001; Quaini et al., 2002; Urbanek et al., 2003; Urbanek et al., 2005; Anversa et al., 2002; Nadal-Ginard et al., 2003), it took the publication of Bergmann et al., 2009, to produce a significant switch in the preval

• Currently because of the lack

  2018-11-08

  

  Currently, because of the lack of biomarkers that identify DSCs specifically, the only way to monitor relative changes in their number and quality is by functional assays. In animal model research, changes in DSCs are monitored by the ability of transplanted donor UNC 0642 to reconstitute recipient

• The following is the supplementary data related

  2018-11-08

  

  The following is the supplementary data related to this article. Author contribution Acknowledgments Introduction Endothelial progenitor increased (EPCs) circulate in peripheral blood and migrate to a site for vascular formation and repair (Asahara et al., 1997). The pro-angiogenic natur

• Our experiments suggest that Runx may be a useful

  2018-11-08

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic buprenorphine hydrochloride manufacturer injury. Runx1 over-expression has been demonstrated to facilitate neuronal d

• br Material and methods br Results

  2018-11-08

  

  Material and methods Results Discussion Aging-associated phenotype change in hBMSCs is one of the most important considerations in furthering the advancement of cell-based therapy and is a subject of numerous studies and reviews (Baker et al., 2015; Bara et al., 2014). In regard to the in v

• br Materials and methods br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments We are grateful to Prof. Angel Raya for his help and advice with iPS cell generation. This work was supported by grants from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER) (grant 13-717/132.05

• The catenindependent Wnt signaling pathway is also important

  2018-11-08

  

  The β-catenindependent Wnt signaling pathway is also important in the modulation of cell proliferation, cell survival, and embryo development [74–76] and is also identified as a regulator of stem cell fate determination [77,78]. It was found that phosphorylation levels of c-Myc and β-catenin (target

• We exploited the fact that

  2018-11-08

  

  We exploited the fact that the eHBs were trapped as progenitors to analyze the effect of specific growth factors upon them and uncovered a central role for FGF (Figure 6). These data are consistent with studies in which FGF promoted the expansion of BL-CFCs derived from human or murine ESCs (Faloon

• br Author Contributions br Acknowledgments br Introduction

  2018-11-08

  

  Author Contributions Acknowledgments Introduction Alpha-1 antitrypsin deficiency (AATD) is a common genetic cause of both liver and lung disease affecting an estimated 3.4 million patients worldwide (de Serres, 2002). The most common disease variant is caused by an inherited single lenvatin

• br Material and methods br Results br Discussion CHI usually

  2018-11-08

  

  Material and methods Results Discussion CHI usually results in severe and permanent neurological impairment. However, there is no single effective therapy for neurological deficits (Kumar and Loane, 2012). Additionally, there is no single animal model reproducing the entire spectrum of neur

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